Topic 188

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29 items. Top items listed below.

Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure 188 10

The central THαβ immunity associated cytokine: IL-10 has a strong anti-tumor ability toward established cancer models in vivo and toward cancer cells in vitro 188 27 10 3

Sodium valproate protects against neuronal ferroptosis in epilepsy via suppressing lysyl oxidase 188 10 3

Regression of Human Breast Carcinoma in Nude Mice After Adsflt Gene Therapy is Mediated by Tumor Vascular Endothelial Cell Apoptosis 188 10 3

Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor 188 10

An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy. 188 153 10

Ermin deficiency as an inside-out model of inflammatory dysmyelination 188 65 3

Enhanced anti-amyloid effect of combined leptin and pioglitazone in APP/PS1 transgenic mice 188 32 10 3

U2AF1 is a haplo-essential gene required for cancer cell survival 188 126 14 10 3

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis 188 32 10 3

A novel Ataxin-3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities 188 65 9 3

CD38 dependent NAD+ depletion contributes to oligodendrocyte loss and inhibition of myelin regeneration 188 10 3

Neuromotor impairment, hearing loss and blindness in a preclinical mouse model of Charcot Marie-Tooth disorder 188 10

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy 188 94 10 3

Optogenetic activation of spinal microglia triggers chronic pain in mice 188 110 11 10 3

AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease 188 65 10

Precise Localization and Dynamic Distribution of Japanese Encephalitis Virus in theBrain Nuclei of Infected Mice 188 116 10

Masitinib mediates TGF-Beta1 and Nitric Oxide Secretion and Ameliorates MPTP/Microglia-Induced Degeneration of Differentiated SH-SY5Y Cells 188 110 10 3

Alk1 mutant endothelial cells undergo clonal expansion in mouse brain arteriovenous malformations 188 94 10 3

Modeling disease progression in newly diagnosed type 2 diabetes 188 64 15 10

Immune Inhibitor A Metalloproteases Contribute to Virulence in Bacillus Endophthalmitis 188 7

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype 188 10 3

Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection 188 27 10

An anti-amyloidogenic treatment to specifically block the consolidation of traumatic events in mouse 188 113 10

SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions 188 126 14 10

Relative contribution of non-structural protein 1 in dengue pathogenesis 188 10

Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria 188 64

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge: implications for Rett Syndrome. 110 27 10 3

Metabolomic signature of the maternal microbiota in the fetus 188 101 12 10

Early-life stress facilitates the development of Alzheimer's disease pathology via angiopathy 32 10 3 2

Life-long persistence of infectious Zika virus: Inflammation and behavioral sequela 27 10

Neuronal LXR Regulates Neuregulin-1 Expression and Sciatic Nerve-Associated Cell signaling 168 11 3

HAP-multitag, a PET and positive MRI contrast nanotracer for the longitudinal characterization of vascular calcifications in atherosclerosis 188 59

Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimers disease 32 10 2

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice 101 10 3

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration 110 32 27 10 3

AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular Dementia 110 10 3

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy 124 65 11 10 2

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model 164 32 10 2

Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31 164 10

Chemogenetic activation of astrocytes in the hippocampus and cortex changes the transcriptome of microglia and other cell types. 120 11 3

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans 32 10 9 3

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation 10 3

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes 109 64 10 3

Sexually dimorphic responses to MPTP found in microglia, inflammation and gut microbiota in a progressive monkey model of Parkinson's disease 164 54 10 2

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis 174 27 10

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo 54 30 10

Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease 54 11 10 3 2

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia 10 3

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells 88 27 10 3

NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female Mice 32 10

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia 32 10 9 3

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain 113 10

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice 32 10 3

Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function 10 3

Prostacyclin promotes degenerative pathology in a model of Alzheimer's disease 32 10 3

Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons 77 11 10 3 2

Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity 110 39 10 3

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques 164 10

Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice 56 11 2

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy 10

Disease stage-specific pathogenicity of CD138 (syndecan 1)-expressing T cells in systemic lupus erythematosus 174 88 27 10 3

1--4-phenylpiperazine Treatment After Brain Irradiation Preserves Cognitive Function in Mice 110 10 3

Antisense oligonucleotides targeting alpha-synuclein reduce pre-formed fibril-induced Lewy pathology and improve some domains of cognitive and motor performance 54 10

Protection from viral rebound after therapeutic vaccination with an adjuvanted DNA vaccine is associated with SIV-specific polyfunctional CD8 T cells in the blood and mesenteric lymph nodes 88 27 10

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota 65 11 10 2

Production of Noncapped Genomic RNAs is Critical to Sindbis Virus Disease and Pathogenicity 41 27 10 3

Loss of the extracellular matrix molecule tenascin-C leads to absence of reactive gliosis and promotes anti-inflammatory cytokine expression in an autoimmune glaucoma mouse model 110 72 10 3

Effects of optogenetic stimulation of basal forebrain parvalbumin neurons on Alzheimer's disease pathology 32 11 2

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis 61 10 3

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche 57 10 3

JN403, an alpha-7-nicotine-acetylcholine-receptor agonist, reduces alpha-synuclein induced inflammatory parameters of in vitro microglia but fails to attenuate the reduction of TH positive nigral neurons in a focal alpha-synuclein overexpression mouse model of Parkinson's disease. 54 10 3

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease 54 11 9 3

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages 39 10 3

Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma 14 10 3

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression 69 10 3

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice 110 27 10 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease 39 32 10

Pre-existing intratumoral CD8 T cells substantially contribute to control tumors following therapeutic anti-CD40 and polyI:C based vaccination 88 14 10 3

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration 32 11 3

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition 108 14 10 3

Lipopolysaccharide administration alters extracellular vesicles in human lung-cancer cells and mice 10 3

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease 32 11 2

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice 110 11 10 3

Direct reprogramming of astrocytes to neurons leads to functional recovery after stroke 164 11 10 2

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis 10 3

A KCNQ2 variant causing Early Onset Epileptic Encephalopathy increases spontaneous network-driven activity and excitability of pyramidal cells in the layer II/III and V of the motor cortex during a limited period of development 11 2

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 69 10 3

Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism 27 3

Gut Microbiota Mediates the Protective Effects of Andrographolide Inhibits Inflammation and Nonalcoholic Fatty Liver Disease(NAFLD) in High-Fat Diet induced ApoE(-/-) Mice 39 10 3

Adverse neurological effects of short-term sleep deprivation in aging mice are prevented bySS31 peptide 7 3

Sex and estrogen receptor β have modest effects on gene expression in the mouse brain posterior cortex 56 9 2

Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence 110 27 10 3