Topic 7

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Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells 7 3

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3

Simulating bout-and-pause patterns with reinforcement learning 7 2

Noncanonical targeting contributes significantly to miRNA-mediated regulation. 7

Method for identification of heme-binding proteins and quantification of their interactions 7 4

On the diversity of chemical power supply as a determinant of biological diversity 7 5

Binding of the SARS-CoV-2 Spike Protein to Glycans 7 1

Population dynamics and neuronal polyploidy in the developing neocortex 169 7

Calculation of fungal and bacterial inorganic nitrogen immobilization rates in soil 7 5

Dissecting the impact of metabolic environment on three common cancer cell phenotypes 7

MORONET: Multi-omics Integration via Graph Convolutional Networks for Biomedical Data Classification 7 4

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampus 7 3

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes 7 4

Asymmetric representation of aversive prediction errors in Pavlovian threat conditioning 7 2

Nested Stochastic Block Models Applied to the Analysis of Single Cell Data 7 4

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation 7

Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer's disease patients. 7

Rational Design of Minimal Synthetic Promoters for Plants 7

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations 7

The potential role of miR-21-3p in coronavirus-host interplay 7 1

Upregulation and cell specificity of C4 genes are derived from ancestral C3 gene regulatory networks 7 3

Improved detection of tumor suppressor events in single-cell RNA-Seq data 7 4

Measuring both microbial load and diversity with a single amplicon sequencing library 7 4

Biophysical modeling of the SARS-CoV-2 viral cycle reveals ideal antiviral targets 7 1

NK cells acquire PD-1 from the membrane of tumor cells. 7 3

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections 7 1

Loop extrusion model predicts CTCF interaction specificity 7

A predictive model of gene expression reveals the role of regulatory motifs in the mating response of yeast 7

The adaptive architecture is shaped by population ancestry and not by selection regime 7 5

Oncogenic H-Ras Signaling Differentially Targets Replicative and Specialized DNA Polymerases for Depletion 7 3

Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion 7

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression 7 3

Linking the dynamics of chromatin occupancy and transcription with predictive models 7

Imaging LexA degradation in cells explains regulatory mechanisms and heterogeneity of the SOS response 7 3

Interspecific Hybrids Show a Reduced Adaptive Potential Under DNA Damaging Conditions 7 5

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity 7 3

A robust method for generating, quantifying and testing large amounts of Escherichia coli persisters 7 4

Insights into gene expression changes under conditions that facilitate horizontal gene transfer (mating) of a model Archaeon 7

PRER: A Patient Representation with Pairwise Relative Expression of Proteins on Biological Networks 184 7 4

Macroscale network feedback structure of transcriptome during cell fate transition 7

MAGIC: Mosaic Analysis by gRNA-Induced Crossing-over 7 4

miR156-mediated changes in leaf composition lead to altered photosynthetic traits during vegetative phase change 7 5

Sex-Specific Evolution of the Genome-wide Recombination Rate 7 5

Intuitive, reproducible high-throughput molecular dynamics in Galaxy: a tutorial 7 4

Protein context shapes the specificity of domain-peptide interactions in vivo 7

First responders shape a prompt and sharp NF-κB-mediated transcriptional response to TNF-α 7 3

Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex 7 1

The major genetic risk factor for severe COVID-19 is inherited from Neandertals 7 1

Scale-free structure of cancer networks and their vulnerability to hub-directed combination therapy 7

Conformational state switching and pathways of chromosome dynamics in cell cycle 7

Structure of the full SARS-CoV-2 RNA genome in infected cells 1

LIVE-PAINT: Super-Resolution Microscopy Inside Live Cells Using Reversible Peptide-Protein Interactions 7 4

Three hallmarks of malaria-induced selection in human genomes 7 5

Antithetic integral feedback for the robust control of monostable and oscillatory biomolecular circuits 7 4

Anti-frameshifting ligand active against SARS coronavirus-2 is resistant to natural mutations of the frameshift-stimulatory pseudoknot 7 1

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2 7 3

Exploring the niche concept in a simple metaorganism 7 5

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits 7 3

Generation of clonal male and female mice through CRISPR/Cas9-mediated Y chromosome deletion in embryonic stem cells 7 3

Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species 7 3

Designer protein assemblies with tunable phase diagrams in living cells 7

Allostery through DNA drives phenotype switching 7 3

MicroRNA-19b regulates proliferation and differentiation along the medial-lateral axis of the developing avian pallium 7 3

Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation 7

Evolutionary Based Adaptive Dosing Algorithms: Beware the Cost of Cumulative Risk 7

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus 7 1

Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV 7 1

Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors 7 3

cAMP bursts control T cell directionality by actin cytoskeleton remodeling 7 3

Categorical judgments do not modify sensory information in working memory 7 2

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation 7 1

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation 7 3

Confidence in action: differences between perceived accuracy of decision and motor response 7 2

Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo 7 3

Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit 7

Renal carcinoma is associated with increased risk of coronavirus infections 7 1

Identification of compounds producing non-visual photosensation via TrpA1 in zebrafish 170 7

In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues 7 4

Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms. 7

A CRISPR-based SARS-CoV-2 diagnostic assay that is robust against viral evolution and RNA editing 35 7 1

Dietary and pharmacological induction of serine synthesis genes 7

Age Influences on the Molecular Presentation of Tumours 7 5

Aneuploid cells activate NF-κB to promote their immune clearance by NK cells 7 3

TuNR: Orthogonal Control of Mean and Variability of Endogenous Genes in a Human Cell Line 169 7

Expression of HPV oncogenes from a single integration site in cervical cancer cell lines 7 3

Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells 36 1

DiffNets: Self-supervised deep learning to identify the mechanistic basis for biochemical differences between protein variants 7

ARG1 could be expressed by human, but not represent for repair 7

Model-based design and analysis of life table experiments for insect vectors 7 4

Two classes of active transcription sites and their roles in developmental regulation 7 3

Consensus Finder web tool to predict stabilizing substitutions in proteins 7 4

Identification of miRNA signatures for kidney renal clear cell carcinoma using the tensor-decomposition method 7 4

Loss of HOXB13 expression in neuroendocrine prostate cancer 7 3

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM 7

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 51 7 3

Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization 7 3

Human Whole Genome Sequencing in South Africa 7 4

Mitochondrial uncoupling protein 2 (UCP2), but not UCP3, is sensitive to oxygen concentration in cells 7 3

A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque 103 73 1

Probabilistic divergence of a TBM methodology from the ideal protocol 7 4