Topic 72

retinal retina ganglion photoreceptor visual vision degeneration rgcs photoreceptors retinas rgc rod neuroscience cone amacrine bipolar cones optic cells mouse light eye rods rpe loss macular retinitis pigmentosa cell pigment outer zebrafish function degenerative blindness mice glaucoma photosensitive inner axon diseases phototransduction neurons responses muller axons neurodegeneration glia types blinding inherited iprgcs melanopsin photopic nerve electroretinogram rhodopsin off degenerating horizontal axonal pathway regeneration vertebrate expressed death age intrinsically glaucomatous restoration normal survival segments circadian adult scotopic dendrites type stimulation synaptic macaque atoh7 circuit epithelium brain response photoreception dysfunction cause developmental rp chiasm dim layer iprgc amd opsin image neurodegenerative ocular

138 items. Top items listed below.

Focal Electrical Stimulation of Human Retinal Ganglion Cells 72 59 2

AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3

Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night vision 72 11 2

Otx2 stimulates adult retinal ganglion cell regeneration. 72 11 3

A unique and evolutionarily conserved retinal interneuron relays rod and cone input to the inner plexiform layer 72 11 2

Regeneration of Functional Retinal Ganglion Cells by Neuronal Identity Reprogramming 72 11 2

Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration 72 57 10

OTX2 non-cell autonomous activity regulates inner retinal function 72 11 3

Tbr2-expressing retinal ganglion cells are ipRGCs 72 20 3

MOLECULAR IDENTIFICATION OF SIXTY-THREE AMACRINE CELL TYPES COMPLETES A MOUSE RETINAL CELL ATLAS 72 43 9

Feedback from retinal ganglion cells to the inner retina 72 50 11 2

Functional Organization of Midget and Parasol Ganglion Cells in the Human Retina 72 2

Functional study of the AMD-associated gene TMEM97 in retinal pigmented epithelium using CRISPR interference 72 9 3

Rod signals are routed through specific Off cone bipolar cells in primate retina 72 50 11 2

CELL ATLAS OF THE HUMAN FOVEA AND PERIPHERAL RETINA 72 43 9

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa 72 11 3

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions in the murine retina 72

Visual properties of human retinal ganglion cells 72 2

CELL ATLAS OF THE CHICK RETINA: SINGLE CELL PROFILING IDENTIFIES 136 CELL TYPES 72 43 9

Atoh7-independent specification of retinal ganglion cell identity 133 72 20 3

A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia 72 11 2

Regulation of retinal neurogenesis by somatostatin signaling. 72 20 3

Suppression without inhibition: A novel mechanism in the retina accounts for saccadic suppression 72 50 23 2

Visual function restoration in genetically blind mice via endogenous cellular reprogramming 72 3

A critical role for MSI1 and MSI2 in photoreceptor morphogenesis 72 20 3

Identification of multiple noise sources improves estimation of neural responses across stimulus conditions 72 38 2

Time-resolved expression analysis comparing two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative regulatory networks. 72 20 9 3

Indirect traumatic optic neuropathy after head trauma in adolescent male mice is associated with behavioral visual impairment, neurodegeneration, and elevated endoplasmic reticulum stress markers at acute and subacute times. 164 72 69 10 2

Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision 72 11

Selective amplification of ipRGC signals accounts for interictal photophobia in migraine 72 23 2

Colors everywhere: enhanced chromatic processing across the first visual synapse in the zebrafish central brain 72 50 2

Proteasome-mediated regulation of Cdhr1a by Siah1 modulates photoreceptor development and survival in zebrafish. 72 3

Age-related degeneration leads to gliosis but not regeneration in the zebrafish retina 72 57 10 3

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development 72 69 3

Genetically-modified X. laevisindicate distinct roles for prominin-1 and photoreceptor cadherin in outer segment morphogenesis and retinal dystrophy 72 34 3

Superior Colliculus-Projecting GABAergic Retinal Ganglion Cells Mediate Looming-Evoked Flight Response 72 11 2

Neuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina 72 27 3

Sfrp1 deficiency makes retinal photoreceptors prone to degeneration 72 3

Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain 72 20 3

An offset ON-OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells 72 50 11 2

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny 72 7 3

GLP-1R agonist NLY01 reduces retinal inflammation, astrocyte reactivity, and retinal ganglion cell death secondary to ocular hypertension. 110 72 10 3

Revival of light-evoked neuronal signals in the post-mortem mouse and human retina 72 11

The projections of ipRGCs and conventional RGCs to retinorecipient brain nuclei 72 50 11 2

Voltage-gated calcium channel subunit α2δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels 72 11 2

Retinal circuits driving a non-image forming visual behavior 72 50 11 2

A single-cell transcriptome atlas of the aging human and macaque retina 72 9

Transcriptome analysis of the zebrafish atoh7-/- mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases 72 20 9 3

Gene Therapy Reforms Photoreceptor Structure and Restores Vision in NPHP5-associated Leber Congenital Amaurosis 72 3

Identification of ADAMTS19 as a novel retinal factor involved in ocular growth regulation 72 3

System Identification with Biophysical Constraints: A Circuit Model of the Inner Retina 72 38 2

Single cell transcriptomics reveals lineage trajectory of the retinal ganglion cells in wild-type and Atoh7-null retinas 72 20 9 3

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction 72 10 3

Motor Protein MYO1C is Critical for Photoreceptor Opsin Trafficking and Vision 72 34 3

Her9/HES4 is required for retinal photoreceptor development, maintenance, and survival 72 20 3

External light dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells 72 29 11 2

Structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells 72 57 11

The visual ecology of Holocentridae, a nocturnal coral reef fish family with a deep-sea-like multibank retina 72 5

A clock in mouse cones contributes to the retinal oscillator network and to synchronization of the circadian system 72 11 3

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress 72 3

Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins 72 20 3

Rod phototransduction and light signal transmission during type 2 diabetes 72 10

Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina 72 33

MCT2 Overexpression Rescues Metabolic Vulnerability and Protects Retinal Ganglion Cells in Two Models of Glaucoma 72 10 3

Optogenetic therapy: High spatiotemporal resolution and pattern recognition compatible with vision restoration in non-human primates 72

The optoretinogram reveals how human photoreceptors deform in response to light 72 18

Metabolic features of mouse and human retinas: rods vs. cones, macula vs. periphery, retina vs. RPE 72 67 3

Optimized culture of retinal ganglion cells and amacrine cells from adult mice 72 57 10

Extracellular vesicles and their miRNA cargo in retinal health and degeneration: mediators of homeostasis, and vehicles for targeted gene therapy. 74 72 10 3

SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration. 72 3

The influence of axial length upon the retinal ganglion cell layer of the human eye 72 15 2

Functional microRNA targetome undergoes degeneration-induced shift in the retina 74 72 3

Melanopsin Carboxy-terminus Phosphorylation Plasticity and Bulk Negative Charge, not Strict Site Specificity, Achieves Phototransduction Deactivation 72 63 3

Nonlinear spatial integration underlies the diversity of retinal ganglion cell responses to natural stimuli 50 23 2

Loss of the extracellular matrix molecule tenascin-C leads to absence of reactive gliosis and promotes anti-inflammatory cytokine expression in an autoimmune glaucoma mouse model 110 72 10 3

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17 72 11 3

Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior 72 11 9

Nonlinear decoding of natural images from large-scale primate retinal ganglion recordings 100 50 26 2

Spontaneous depolarization-induced action potentials of ON-starburst amacrine cells during cholinergic and glutamatergic retinal waves 72 11 2

Reconstruction of natural images from responses of primate retinal ganglion cells 72 23 2

Nonlinearities in retinal bipolar cells shape the encoding of artificial and natural stimuli 72 50 23 2

When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma 164 72 2

Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection 72 9

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells 72 3

The Olivary Pretectal Nucleus Receives Visual Input of High Spatial Resolution 72 50 2

What the Zebrafish's Eye Tells the Zebrafish's Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision 72 2

Exon 13-skipped USH2A protein retains functional integrity in mice, suggesting an exon skipping therapeutic approach to treat USH2A-associated disease. 72 65 3

High resolution visual information via a gap junction-mediated spike order code 50 11 2

The C-terminus and Third Cytoplasmic Loop Cooperatively Activate Mouse Melanopsin Phototransduction 72 63 8 3

Representations of the amacrine cell population underlying retinal motion anticipation 50 23 2

Radial asymmetries around the visual field: From retina to cortex to behavior 72 23 2

Modelling and rescue of RP2 Retinitis Pigmentosa using iPSC Derived Retinal Organoids 72 57 10 3

Selective connectivity limits functional binocularity in the retinogeniculate pathway of the mouse 72 50 11 2

Boolean Implication Analysis Improves Prediction Accuracy of In Silico Gene Reporting of Retinal Cell Types 43 4

Vertebrate features revealed in the rudimentary eye of the Pacific hagfish (Eptatretus stoutii) 72

Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration in the zebrafish retina 72 10 3

Mesoscopic cortical network reorganization during recovery of partial optic nerve injury in GCaMP6s mice 72 50 2

Rest-activity cycles and melatonin phase angle of circadian entrainment in people without cone-mediated vision 72 2

Slit2 is essential for correct retinal ganglion cell axon fasciculation and midline crossing in the zebrafish 72 20 3

POU6F2 Positive Retinal Ganglion Cells a Novel Group of ON-OFF Directionally Selective Subtypes in the Mouse Retina. 72 15