Topic 77

synaptic synapses neuroscience plasticity postsynaptic neurons presynaptic excitatory synapse hippocampal neuronal dendritic glutamate potentiation spine spines release dendrites transmission receptors ltp term ca1 ampa receptor ca2 memory brain inhibitory glutamatergic dependent neuron neurotransmitter nmda depression pyramidal activity neurotransmission vesicle density circuits long learning inputs function strength cortical mediated ltd currents calcium microscopy regulate at connections mechanisms channels electron astrocytes terminals imaging stimulation mice ca3 homeostatic vesicles axons localization formation hippocampus astrocyte axonal circuit photon structural here slices signaling transmitter excitability understood boutons adhesion active thus local astrocytic nervous vivo remains increases changes ampars potentials role quantal functional neuromuscular activation spontaneous

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PKD promotes activity-dependent AMPA receptorendocytosis in hippocampal neurons 77 11 3 2

Ablation of STAT3 in Purkinje Cells Reorganizes Cerebellar Synaptic Plasticity in Long-Term Fear Memory Network 77 11 2

Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1 77 11 2

Postsynaptic serine racemase regulates NMDA receptor function 77 11 3 2

Calcium-permeable AMPA receptors mediate timing-dependent LTP elicited by six coincident action potentials at Schaffer collateral-CA1 synapses 77 11 2

The immediate early gene Arc is not required for hippocampal long-term potentiation. 77 11 3

Extracellular matrix supports excitation-inhibition balance in neuronal networks by stabilizing inhibitory synapses 77 11 2

Neuroligin3 Splice Isoforms Shape Mouse Hippocampal Inhibitory Synaptic Function 77 11 3

Regulation of Hippocampal Excitatory Synapses by the Zdhhc5 Palmitoyl Acyl Transferase 77 11 3

Control of E-S Potentiation at two different sites in the dendro-somatic axis 77 11 2

Molecular diversity of glutamatergic and GABAergic synapses from multiplexed fluorescence imaging 77 11 2

Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity 77 11 3 2

Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in C. elegans 77 11 3

Astrocytic Neurexin-1 Orchestrates Functional Synapse Assembly 77 11 3

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly 77 11 3 2

Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons 77 11 2

Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits 77 11 2

SynaptoPAC, an Optogenetic Tool for Induction of Presynaptic Plasticity 77 11 2

Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons 77 11 2

Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity 77 11 2

Associative Learning and Motivation Differentially Requires Neuroligin-1 at Excitatory Synapses 77 58 11 2

CB1 receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination 77 11 3 2

Extreme stiffness of neuronal synapses and implications for synaptic adhesion and plasticity 77 11 2

Structural and functional synaptic plasticity induced by convergent synapse loss requires co-innervation in the Drosophila neuromuscular circuit 77 11 2

Altered spike timing-dependent plasticity rules in physiological calcium 77 11 2

Time course of homeostatic structural plasticity in response to optogenetic stimulation in mouse anterior cingulate cortex 77 11 2

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals 77 11 2

Increased and synchronous recruitment of release sites underlies hippocampal mossy fiber presynaptic potentiation 77 11 2

Long vs short-term synaptic learning rules after optogenetic spike-timing-dependent plasticity 77 11 2

Modeling the short-term dynamics of in vivo excitatory spike transmission 77 11 2

Idealized model of the developing visual cortex 50 11 2

Syngap1 Dynamically Regulates the Fine-Scale Reorganization of Cortical Circuits in Response to Sensory Experience 77 11 2

Spontaneous Axonal ER Ca2+ Waves Mediate a Shift From Action Potential-Dependent to Independent Glutamate Release in the YAC128 HD-Model 77 69 11 3 2

Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function 77 11 3 2

Dendritic spines are lost in clusters in patients with Alzheimers disease 77 32 11 2

IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation 77 11 2

Disinhibitory and neuromodulatory regulation of hippocampal synaptic plasticity 77 11 3 2

RTP801 Is A Key Modulator For Motor Learning 77 11 2

Astrocytic glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex 104 77 11 2

AMPA receptor anchoring at CA1 synapses is determined by an interplay of N-terminal domain and TARP γ8 interactions 77 7

Heterosynaptic cross-talk of pre- and postsynaptic strengths along segments of dendrites 77 11 2

Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling 77 11 2

Spontaneous single synapse activity predicts evoked neurotransmission by using overlapping machinery 77 11 2

Stable but not rigid: Long-term in vivo STED nanoscopy uncovers extensive remodeling of stable spines and indicates multiple drivers of structural plasticity 77 11 2

Noise in neurons and synapses enables reliable associative memory storage in local cortical circuits 77 50 11 2

Release probability increases towards distal dendrites boosting high-frequency signal transfer 77 11 2

NMDA receptors enhance the fidelity of synaptic integration 77 11 2

Learning excitatory-inhibitory neuronal assemblies in recurrent networks 104 50 11 2

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease 32 11 2

Mesophasic organization of GABAA receptors in hippocampal inhibitory synapse 77 11 8 2

The biophysical basis underlying the maintenance of early phase long-term potentiation 77 11 2

Gamma-protocadherin localization at the synapse corresponds to parameters of synaptic maturation 77 11 3

Distinct mechanisms underlie the subsynaptic mobility of presynaptic metabotropic glutamate receptor types to tune receptor activation 77 11 8 3

Presynaptically silent synapses are modulated by the density of surrounding astrocytes 77 11 2

A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex 77 11 2

Competition for glutamate between NMDA and AMPA receptors prevents runaway synaptic dynamics 77 11

Synaptotagmin-7 is a calcium sensor for facilitation at the splanchnic-chromaffin cell synapse 77 11 3

Herpes Simplex Virus type 1 neuronal infection triggers disassembly of key structural components of dendritic spines 77 11 3

All-Trans Retinoic Acid induces synaptic plasticity in human cortical neurons 77 11 2

Action potential-coupled Rho GTPase signaling drives presynaptic plasticity 77 11 3

Maturation of complex synaptic connections of layer 5 cortical axons in the posterior thalamic nucleus requires SNAP25 77 11 2

Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in Drosophila 77 11 2

Local neuronal secretory trafficking dynamics revealed with zapERtrap: a light-inducible ER release system 77 11 8 3

Morphologically constrained modeling of spinous inhibition in the somato-sensory cortex 77 11 2

Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation 77 11 3

Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons 77 11 10 3 2

Csmd2 interacts with Dab1 and is Required in Reelin-Mediated Neuronal Maturation 77 11 3

Homeostatic Plasticity Requires Remodeling of the Homer-Shank Interactome 77 11 2

IGF-1 facilitates extinction of conditioned fear 77 11 2

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses 77 69 11

Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP 77 11 2

Distinct target-specific mechanisms homeostatically stabilize transmission at pre-and post-synaptic compartments 77 11 3

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits 77 11 3

Rapid 'multi-directed' cholinergic transmission at central synapses 77 11 2

EphA7 Isoforms Differentially Regulate Cortical Dendrite Development 77 11 3 2

Age dependent changes in synaptic NMDA receptor composition in adult human cortical neurons 77 11 2

Plasticity in prefrontal cortex induced by coordinated nucleus reuniens and hippocampal synaptic transmission 66 11 2

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors 77 8

Synaptic anchoring of the endoplasmic reticulum depends on myosin V and caldendrin activity 77 69 11 8 3

X-ray mediated scintillation increases synaptic activity via Cerium-doped LSO and Channelrhodopsin-2 77 11 2

Endophilin A1 promotes Actin Polymerization in response to Ca2+/calmodulin to Initiate Structural Plasticity of Dendritic Spines 77 11 3

Calsyntenin-3 directly interacts with neurexins to orchestrate excitatory synapse development in the hippocampus 77 11 3 2

Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines 77 11 3 2

PKA-mediated phosphorylation of Neuroligin-2 regulates its cell surface expression and synaptic stabilisation 77 11 3

Energetics of BCM type synaptic plasticity and storing of accurate information 77 11 2

Cellular-resolution mapping uncovers spatial adaptive filtering at the cerebellum input stage 77 11 2

Ketamine selectively enhances AMPA neurotransmission onto a subgroup of identified serotoninergic neurons of the rat dorsal raphe 77 11 2

Membrane Ca2+ permeability and IP3R2 dependent Ca2+-induced Ca2+ release are essential for astrocytic intracellular Ca2+ elevation upon neuronal stimulation at the mouse hippocampal CA3 - CA1 excitatory synapses 77 11 3 2

Human SYNGAP1 Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation 65 11 3 2

Growth Rules for the Repair of Asynchronous Irregular Neuronal Networks after Peripheral Lesions 77 11 2

Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse 77 11 2

Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice 61 11 3

Modeling unitary fields and the single neuron contribution to local field potentials in the hippocampus 77 11 2

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling 77 11 9 3

Presynaptic NMDA receptors cooperate with local action potentials to implement activity-dependent GABA release from the reciprocal olfactory bulb granule cell spine 77 11

Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression 7 3

3D ultrastructural study of synapses in the human entorhinal cortex 77 11 2

Astrocytic modulation of information processing by layer 5 pyramidal neurons of the mouse visual cortex 50 11 7 2

Pathway-specific deregulation of striatal excitatory synapses in LRRK2 mutations 77 54 11 3

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to 1 CA1 by differential modulation of feedforward inhibitory circuits 77 11 2