Topic 64

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297 items. Top items listed below.

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor 7 3

Computationally Guided Design of BCR-ABL Tyrosine Kinase Inhibitors 64 44 10

Development of A Novel Highly Selective TLR8 Agonist for Cancer Immunotherapy 166 64 10 3

Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening 44 1

KD-64 - a new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist - caffeine does not reduce diet-induced obesity in mice 39 10

Mimicry of dopamine 1 receptor signaling with Cell-Penetrating Peptides 64 10 3

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes 109 64 10 3

A Strategy to Treat COVID-19 Disease with Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Non-clinical Pharmacokinetic Study 44 1

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig 64 44 10

Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy 64 44 1

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) 64 39 10 3

The Effect Of Famotidine On SARS-CoV-2 Proteases And Virus Replication 44 1

A novel drug-combination screen in zebrafish identifies epigenetic small molecule candidates for Duchenne muscular dystrophy 64 44 10

Large-Scale Transcriptional Profiling of Molecular Perturbations Reveals Cell Type Specific Responses and Implications for Environmental Screening 64 9

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators 44 1

Continuous administration of the p38α inhibitor neflamapimod during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level 64 10

Hesperetin inhibits foam cell formation in macrophages via activating LXRα signal in an AMPK dependent manner 64 10 3

Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Mice 7

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model 153 64 10

Differential GLP-1R binding and activation by peptide and non-peptide agonists 64 51 8

Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling 64 3

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation 10 3

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy 64 14 10 3

Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques 64 44 1

Schistosomes alter expression of immunomodulatory gene products following in vivo praziquantel exposure 166 64 10 3

Combined Vapor Exposure to THC and Alcohol in Pregnant Rats: Maternal Outcomes and Pharmacokinetic Effects 141 64 15 10

The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms 64 10

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells 64 33 3

Neuronal Population Models Reveal Specific Linear Conductance Controllers Sufficient to Rescue Preclinical Disease Phenotypes 7 4

KDS2010, a newly developed reversible MAO-B inhibitor, as an effective therapeutic candidate for Parkinson's disease 64 54 10

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways. 7

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2 7 1

Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure 64 10

Modulation of Human T-type Calcium Channels by Synthetic Cannabinoid Receptor Agonists in vitro 64 10

Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy 64 10

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor 64 10 3

CETSA MS profiling for a comparative assessment of FDA approved antivirals repurposed for COVID-19 therapy identifies Trip13 as a Remdesivir off-target 44 41 1

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids. 64 10 3

A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats 64 15 10

Effects of date fruit (Phoenix dactylifera) on sperm cell morphology and reproductive hormonal profiles in cypermethrin-induced male infertility 141 64 15 10

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity. 7

The possible anti-inflammatory activity of macrolide antibiotics in some animal models 64 10

Effects of salvianolic acid A on β-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease 32 10

Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids 153 126 64 14 10 3

Bixafen, a succinate dehydrogenase inhibitor fungicide, causes microcephaly and motor neuron axon defects during development 64 10

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations 7

Effect of pesticides and metals on zebrafish embryo development and larval locomotor activity 64 15

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro 44 1

Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer's disease model 32 10

Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling 82 64 8

Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro 44 1

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model 64 10

Discovery of A New Class of Integrin Antibodies for Fibrosis 64 10 3

Repurposing Pyramax for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate 64 44 10

Female rats self-administer heroin by vapor inhalation 141 64 15 10

Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2. 36 1

Analyzing cannabinoid-induced abnormal behavior in a zebrafish model 64 15 10

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression 64 10 3

Cell Pluripotency and Its Effect on Sensitivity to Chemical Exposure 64 57 15 10

BCL-XL is essential for the protection from secondary anemia caused by radiation-induced fatal kidney damage 64 10 3

Computational design of two new soluble epoxide hydrolase (sEH) inhibitors 64 10

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity 7 3

Fluoxetine treatment prevents cardiovascular changes in baroreflex and chemoreflex in rats subjected to chronic stress 141 64 10

Chronic low-dose dioxin exposure accelerates high fat diet-induced hyperglycemia in female mice 109 39 10 3

The 'C3aR antagonist' SB290157 is a partial C5aR2 agonist 64 10

CM93, a novel covalent small molecule inhibitor targeting lung cancer with mutant EGFR 126 64 14 10 3

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor 64 63 8

In vivo characterisation of the toxicological properties of DPhP, one of the main degradation products of aryl phosphate esters. 64 45 10

Acute toxicity of Leaf extracts of Enydra fluctuans Lour in Zebrafish (Danio rerio Hamilton) 64 15 10

Modeling the dynamics of antibody-target binding in living tumors 64 14 8

Magnesium Sulfate Attenuates Lethality and Oxidative Damage Induced by Different Models of Hypoxia in Mice 7

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 7 3

Computationally Guided Design of Novel Selective Serotonin Reuptake Inhibitors 64 15

In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2 44 1

Multi-omics phenotyping of the gut-liver axis allows health risk predictability from in vivo subchronic toxicity tests of a low-dose pesticide mixture 64 12 9

Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship 64 10

In Vitro Assessment of Antioxidant activity, Antimicrobial, and cytotoxicity of ultrasound-assisted acetone extracts of Plectranthus amboinicus 64 15 10

Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice 64 10

Glutamic acid promotes hair growth in mice 64 10 3

Methylene Blue Inhibits In Vitro the SARS-CoV-2 Spike - ACE2 Protein-Protein Interaction - A Mechanism That Can Contribute to Its Antiviral Activity Against COVID-19 44 1

Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein 64 10

Evaluation of Neuropharmacological Effects of Different Chemical Extracts of Flemingia Stricta (Roxb.) Leaves. 64 10

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease 44 1

Carbon dots deposition in adult bones reveal areas of growth, injury and regeneration 64 10

A novel HER2-targeted antibody-drug conjugate offers the possibility of clinical dosing at trastuzumab-equivalent exposure levels 64 10

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis 150 64 3

Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement 7

Tocotrienol decreases β-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease 32 10

Immunosuppressive effect of the Fusarium secondary metabolite butenolide in human colon epithelial cells. 110 64 10 3

Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy 64 10 3

Anti-inflammatory Activity of Lefamulin in a Lipopolysaccharide-Induced Lung Neutrophilia Model 64 10

Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice 64 44 10

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports 7

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin 64 10 3

Functional Evidence for Biased Inhibition of G protein Signaling by YM-254890 in Human Coronary Artery Endothelial Cells 64 10 3

Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins 7 1

Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model 64 10

Isoproterenol-induced Cardiac Dysfunction in Male and Female C57Bl/6 Mice 141 64 15 10

REV-ERB Agonism Improves Liver Pathology in a Mouse Model of NASH 64 39 10 3

Prohibitin protects against cigarette smoke extract-induced cell apoptosis in cultured human pulmonary microvascular endothelial cells 64 3