Topic 3

cells cell biology expression signaling protein regulation activation mediated transcription role dependent induced regulates function factor pathway regulated transcriptional cancer mechanism proteins cellular required regulator regulate kinase binding loss mice promotes formation vivo inhibition differentiation developmental molecular mouse essential mutant proliferation mechanisms regulatory receptor regulating membrane homeostasis activity stem growth activated phosphorylation pathways tumor response vitro stress show gene levels genes functions increased chromatin promote defects immune expressed roles beta here via nuclear through mutants critical reduced domain rna inflammatory type involved conserved deficient factors deletion together depletion during upon understood regulators target development unknown plays induces immunology leads progression

8877 items. Top items listed below.

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila 134 31 9 3

AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 150 110 49 3

The landscape of metabolic pathway dependencies in cancer cell lines 186 9 3

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells 20 3

UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms 142 3

β-catenin-Mediated Wnt Signal Transduction Proceeds Through an Endocytosis-Independent Mechanism 20 3

SOX9 is sufficient to drive endothelial cells towards a mesenchymal fate by altering the chromatin landscape. 31 20 3

Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells 69 3

GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1 20 9 3

A novel role for the C-terminal domain of the influenza A virus host shutoff endoribonuclease PA-X in mediating rapid turnover of the PA-X protein 41 3

Phosphoproteomics after nitrate treatments reveal an important role for PIN2 phosphorylation in control of root system architecture. 16 9 3

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target 108 14 3

Alteration of the premature tRNA landscape by gammaherpesvirus infection 49 41 31 9 3

The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint 102 34 3

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals 102 3

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication 41 27 3

Functional and structural basis of extreme non-coding conservation in vertebrate mRNAs 134 49 31 9 3

Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function 27 10 3

ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells 31 3

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition 49 20 3

Aging leads to stochastic loss of silencing at transposons in mammary luminal epithelial cells 81 31 9 3

Identification of a new regulation pathway of EGFR and E-cadherin dynamics 102 34 3

Akt is required for artery formation during embryonic vascular development 94 20 3

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation 51 8 3

WSB1 Regulates c-Myc Expression Through β-catenin Signaling and Forms a Feedforward Circuit Promoting the Development of Cancer. 108 14 3

Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG 186 95 3

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles 54 3

Docosahexaenoic acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain 57 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression 7 3

Differential transcriptional reprogramming by wild type and lymphoma-associated mutant MYC proteins as B-cells convert to lymphoma-like cells 142 9 3

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate 20 3

NLRP3 controls ATM activation in response to DNA damage. 46 3

ELAVL1 Primarily Couples mRNA Stability with the 3'UTRs of Interferon Stimulated Genes 49 27 3

Co-expression signatures of combinatorial gene regulation 134 31 9 3

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colon cancer cells 142 108 3

Alpha-synuclein supports interferon stimulated gene expression in neurons 54 27 10 3

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes 31 3

Gene co-expression analysis of human RNASEH2A reveals functional networks associated with DNA replication, DNA damage response, and cell cycle regulation 120 9 3

PQS-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa 52 12 10 3

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production 41 3

Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology 32 31 3

Oncogenic H-Ras Signaling Differentially Targets Replicative and Specialized DNA Polymerases for Depletion 7 3

Real-time measurement of E2:ERα transcriptional activity in living cells. 102 3

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity 88 27 14 10 3

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system 114 27 3

Exportin Crm1 is important for Swi6 nucleocytoplasmic shuttling and MBF transcription activation in Saccharomyces cerevisiae 34 3

Brucella suppress innate immunity by down-regulating STING expression in macrophages 174 27 3

Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer 102 34 3

Chemogenetic activation of astrocytes in the hippocampus and cortex changes the transcriptome of microglia and other cell types. 120 11 3

The conserved herpesviral kinase ORF36 activates B2 retrotransposons during murine gammaherpesvirus infection 31 3

Defining a critical enhancer near Nanog using chromatin-focused approaches identifies RNA Pol II recruitment as required for expression 31 9

Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism 27 3

N6-methyladenine DNA demethylase ALKBH1 regulates mammalian axon regeneration 3

A single N6-methyladenosine site in lncRNA HOTAIR regulates its function in breast cancer cells 49 31 3

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae 69 34 3

Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration. 102 3

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α. 150 27 3

The low complexity regions in the C-terminus are essential for the subcellular localisation of Leishmania casein kinase 1 but not for its activity 34 3

Functional mapping of androgen receptor enhancer activity 31 9 3

Comparative gene expression in cells competent in or lacking DNA-PKcs kinase activity following etoposide exposure reveal differences in gene expression associated with histone modifications, inflammation, cell cycle regulation, Wnt signaling, and differentiation. 108 3

The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans 102 79 3

Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. 146 88 27 3

Functional impact and regulation of global alternative splicing patterns in heart development and disease 120 9 3

CHD4-NURD controls spermatogonia survival and differentiation 20 3

RUNX1 mitotically bookmarks target genes that are important for the mammary epithelial-to-mesenchymal transition 98 31 20 3

Zn2+ influx activates ERK and Akt signaling pathways through a common mechanism 102 3

Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses 150 27 3

The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress 90 3

The histone variant H2A.Z is required to establish normal patterns of H3K27 methylation in Neurospora crassa 93 31 9 3

The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes 31 20 9 5

Timed mesodermal FGF and BMP govern the multi-step thyroid specification 118 20 3

The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster. 192 133 20 3

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells 150 88 27 3

A toxin-antitoxin system associated transcription factor of Caulobacter crescentus can influence cell cycle-regulated gene expression during the SOS response 79 3

p53 plays a central role in lymphatic anomalies 94 3

Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth via a mast cell-dependent pathway 108 14 10 3

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling 69 34 3

Transcription factor binding dynamics shape noise across biological processes 134 31 9 3

Peptide-based Inhibitors of Protein-Protein Interactions of Src Homology 2 Domain-Containing Phosphatase 2 102 63 3

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution 120 43 9 3

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance 108 102 14 3

Multi-organ signaling mobilizes tumor-associated erythroid cells expressing immune checkpoint molecules 14 10 3

HSATII RNA is induced via a non-canonical ATM-regulated DNA-damage response pathway and facilitates tumor cell proliferation and movement 108 14 3

Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion 102 3

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning 89 7 3

Analysis of genomic DNA methylation and gene transcription modulation induced by DNMT3A deficiency in HEK293 cells 93 31 9 3

Bipartite influence of abscisic acid on xylem differentiation trajectories is dependent on distinct VND transcription factors in Arabidopsis 16 3

Functional melanoma cell heterogeneity is regulated by MITF-dependent cell-matrix interactions 108 14 3

Genome-scale mapping reveals complex regulatory activities of RpoN in Yersinia pseudotuberculosis 79 31 12 9 3

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3

Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells 98 14 3

An interaction between Gβγ and RNA polymerase II regulates transcription in cardiac fibroblasts 119 102 3

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity 102 3

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors 142 108 14 3