Topic 82

channels channel voltage gated ion potassium sodium calcium clamp ca2 currents pore membrane gating action patch neurons activated excitability activation na current biophysics conductance electrophysiological hyperpolarization potential neuroscience transmembrane firing opening electrical extracellular nav1 selective potentials function cation recordings physiology cardiac domain activity subunits depolarization electrophysiology pain neuronal sensitive influx resting cyclic intracellular receptors inward dependent modulation transient bk type receptor inhibition leak kinetics hcn modulate sensory coupling synaptic properties release heart selectivity functional sensing mechanism myocytes residue nav mechanical induced binding expressed residues sensor pyramidal slices sensors mediated neurotransmitter ap s4 gate opens subunit spontaneous permeable vsd nalcn critical

154 items. Top items listed below.

Alternative splicing tunes sodium channels to support channel- and neuron- specific effects 82 11 2

Focused ultrasound excites neurons via mechanosensitive calcium accumulation and ion channel amplification 82 11 2

Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins 82 69 34 3

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3

Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity 82 11 2

Nonspecific membrane interactions can modulate BK channel activation 163 82 8 3

Nav1.7 gating in human iPSC derived sensory neurons: an experimental and computational study 82 11 10

Dynamic changes in β-cell electrical activity and regulates NFATc3 activation and downstream gene transcription 109 82 3

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel 82 11

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex 82 51 8 3

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling 82 3

Optical measurement of physiological sodium currents in the axon initial segment 82 11 2

Spike-frequency dependent inhibition and potentiation of neural activity by ultrasound 82 11 2

Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface 163 82 63 8 3

Multiple binding sites for resin-acid derivatives on the voltage-sensor domain of the Shaker potassium channel 163 82 8 3

Excitatory GABAergic modulation of calyx terminals in the vestibular sensory end organ 82 11 2

Why are voltage gated Na channels faster than K channels? One multi-scale hierarchical model 82 8

Optical measurement of voltage sensing by endogenous ion channel 82 70 18 8

Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons 82 11 3 2

Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp 82 18 4

An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel 82 8 3

Differential inhibition of GABA release from mouse hippocampal interneuron subtypesby the volatile anesthetic isoflurane 104 82 11 2

SLO2.1 and NALCN form a functional complex to modulate myometrial cell excitability 82 34 3

Mechanism and site of action of big dynorphin on ASIC1a 82 63 8 3

Graded calcium spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of mouse spinal cord 82 11 2

Proton-Dependent Inhibition, Inverted Voltage Activation, and Slow Gating of CLC-0 Chloride Channel 82 8

Kcns3 Deficiency Disrupts Parvalbumin Neuron Physiology in Mouse Prefrontal Cortex: Implications for the pathophysiology of schizophrenia 82 11 2

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems 82 18

Network analysis reveals how lipids and other cofactors influence membrane protein allostery 82 8

Paradoxical relationships between active transport and global protein distributions in neurons 82 38 8

Structure of human sodium leak channel NALCN in complex with FAM155A 82 51 8 3

Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical Slices 82 11 10 2

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening 82 51 7 3

Cannabidiol Interactions with Voltage-Gated Sodium Channels 82 63 8

Plasticity manifolds: Conjunctive changes in multiple ion channels mediate activity-dependent plasticity in hippocampal granule cells 82 11 2

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice 82 3

Early life stress targets the transcriptional signature and functional properties of voltage gated-sodium (Nav) channels in hippocampal NG2+ glia. 82 11 9 3

Dendritic spikes in apical oblique dendrites of cortical layer 5 pyramidal neurons 82 50 11 2

Mg2+ modulates the activity of hyperpolarization-activated calcium currents in plant cells 82 8 3

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5 82 3

HCN domain is required for HCN channel expression and couples voltage- and cAMP-dependent gating mechanisms 82 51 8 3

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ 109 82 10 3

A mathematical investigation of chemotherapy-induced peripheral neuropathy 82 11 10

Neuropathic Pain Linked to Defective Dopaminergic Inhibition in Anterior Cingulate Cortex 82 11 2

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization 82 63 8 3

Fragile X Mental Retardation Protein modulates somatic D-type K+ channels and action potential threshold in the mouse prefrontal cortex 82 11 2

Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling 82 64 8

Peripheral voltage-gated calcium channels in skin are essential for transient neurogenic thermal hyperalgesia in mice 82 11 10 3

Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA 82 11 10 3

Specific PIP2 Binding Promotes Calcium Activation of TMEM16A Chloride Channels 82 63 8 3

A KCNQ2 variant causing Early Onset Epileptic Encephalopathy increases spontaneous network-driven activity and excitability of pyramidal cells in the layer II/III and V of the motor cortex during a limited period of development 11 2

The mechanism of analgesia in Nav1.7 null mutants 82 11 3 2

Studies on CRMP2 SUMOylation-deficient transgenic mice reveal novel insights into the trafficking of NaV1.7 channels 82 11 3

Deletion of Trpm4 alters the function and expression of NaV1.5 channel in murine cardiac myocytes 82 10 3

Cholinergic modulation of membrane properties of calyx terminals in the vestibular periphery 82 11 2

Modulation of Recombinant Human T-type calcium channels by Δ9-tetrahydrocannabinolic acid in vitro 82 64 10

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates 82 8

Lamellar cells in Pacinian and Meissner corpuscles are touch sensors 82 11

Circadian rhythms of early afterdepolarizations and ventricular arrhythmias in a cardiomyocyte model 82

Neuronal Hyperexcitability is a DLK-dependent Trigger of HSV-1 Reactivation that can be Induced by IL-1 82 27 3

ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem. 82 11 2

On the Origin of Ultraslow Spontaneous Na+ Fluctuations in Neurons of the Neonatal Forebrain 11 2

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments 82 38 18

The trajectory of discrete gating charges in a voltage-gated potassium channel 82 8

The KCNQ4-mediated M-current regulates the circadian rhythm in mesopontine cholinergic neurons 82 11 3

Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study 82 38

The sodium leak channel complex is voltage sensitive and directly modulated by extracellular calcium 82 11 3

Disease-Linked Super-Trafficking of a Mutant Potassium Channel 82 3

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy 82 65 11 3

Voltage-gated Ca2+ and K+ channel coupling regulates CA1 hippocampal synaptic filtering and spine excitability 77 11 3

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability 124 65 11 10 3 2

GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals 82 77 11 3

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neurons 82 38 11 2

The Potassium Channel Subunit Kvβ1 is Required for Synaptic Facilitation 77 11 2

Sodium leak channel as a therapeutic target for neuronal sensitization in neuropathic pain 82 11 10 3

Optically Activated, Customizable, Excitable Cells- A Kuhl Platform for Evolving Next Gen Biosensors 82 18

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability 32 11 3

A Piezo1 open state reveals a multi-fenestrated ion permeation pathway 82 78 8

Calcium induced calcium release in proximity to hair cell BK channels revealed by PKA activation 82 11 3

Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons 124 82 65 11 10

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization 82 11

Novel target identification using single cell sequencing and electrophysiology of cardiac sympathetic neurons in disease 82 11 10 3

Synaptic contributions to cochlear outer hair cell Ca2+ homeostasis 82 77 11 3

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels 82 3

A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes 82 63 8 3

Voltage-gated ion channels mediate the electrotaxis of glioblastoma cells in a hybrid PMMA/PDMS microdevice 82 18

NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity 163 82 8

Functional and Pharmacological Evaluation of a Novel SCN2A Variant Linked to Early-onset Epilepsy 82 64

Viral channelrhodopsins: calcium-dependent Na+/K+ selective light-gated channels 82 8 3

β-adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins 82 34 3

Divergent ion selectivity and sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs of DEG/ENaC/ASIC channels in C. elegans 82 8

Spike-frequency adaptation is modulated by interacting currents in an Hodgkin-Huxley-type model: Role of the Na,K-ATPase 82 38 2

The main activatory and tension-sensitive transitions occur within Prozac sensitive down-states of the potassium selective TREK-2 channel 82 8

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels 82 51 8

Voltage-gated potassium channels ensure action potential shape fidelity in distal axons 82 11 2

Structure of the ancestral TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium 51 8 3

TRPA1 channels are a source of calcium-driven cardiac mechano-arrhythmogenicity 82 3

The floor-plate of His is a non-neuronal electrical conduction pathway 82 11 2

L-type calcium channel contribution to striatal dopamine release is governed by calbindin-D28K, the dopamine transporter, D2-receptors, α2δ-subunits and sex differences 82 11 3

RubyACRs, non-algal anion channelrhodopsins with highly red-shifted absorption 82 63 8