Topic 156

bone marrow mice signaling osteoblasts increased differentiation deletion skeletal bones osteoclasts induced expression osteoclast beta regulates homeostasis injury osteoclastogenesis activation deficiency regulator cells resorption loss trabecular cell vitro wnt cartilage mesenchymal osteoporosis osteogenic levels osteoblast pathway epithelial reduced tgf muscle osteocytes receptor rankl were mass phenotype during tissue inhibiting together mature collagen downregulated vivo adult biology murine osteogenesis cultured dysfunction marker growth stromal inflammatory bm canonical taken protein enhanced after progenitor remodeling role mineralization regeneration developmental formation mrna myogenesis myoblast thm1 regulation mechanical aberrant morphogenetic endosteal matrix activator muscles impaired adipocyte adipocytes fragility proliferation inflammation media kidney age controls calcified

51 items. Top items listed below.

Adipose-tissue derived signals control bone remodelling. 156 150 57 10 3

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo 156 57 3

Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss 156 57 3

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice 156 20 3

RANKL from Bone Marrow Adipocytes Regulates Osteoclast Formation and Bone Loss in Mice 156 57 3

CD13 is a Critical Regulator of Cell-cell Fusion in Osteoclastogenesis 156 7 3

SMAD2 promotes myogenin expression and terminal myogenic differentiation. 156 102 3

YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation for fracture repair 156 57 20 3

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity 156 57 3

Delineating the relationship between immune system aging and myogenesis in muscle repair 156 27 10 3

Inorganic Pyrophosphate Promotes Osteoclastogenic Commitment and Survival of Bone Marrow Derived Monocytes mediated by Egr-1 up-regulation and MITF phosphorylation 156 102 3

Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage anlagen. 156 85 57 10 3

MiR-146a controls age related bone loss 156 3

The TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading through actions on sensory nerves and osteoblasts 156 10 3

Propranolol and parathyroid hormone synergistically improve bone volume fraction by suppressing resorption 156 10 3

ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy 156 3

Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish 156 3

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. 156 110 10 3

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis 156 3

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease 156 3

Dmp1Cre-directed knockdown of PTHrP in murine decidua is associated with increased bone width and a life-long increase in strength specific to male progeny 156 15 10 3

PPARG in osteocytes is essential for sclerostin expression, bone mass, marrow adiposity and TZD-induced bone loss 156 3

Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells 156 57 10 3

Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling 156 85 57 3

TSG Targeting KDM5A affects osteogenic differentiation of bone mesenchymal stem cells induced by bone morphogenetic protein 2 156 57 3

Intraflagellar transport-A deficiency ameliorates ADPKD in a renal tubular- and maturation-dependent manner 156 95 3

Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy 156 98 3

Selective role of Nck1 in atherogenic inflammation and plaque formation 156 150 3

Drosophila Activin signaling promotes muscle growth through InR/dTORC1 dependent and independent processes 156 3

CD40 provides immune privilege to the bone marrow hematopoietic niche 156 27 10 3

Regulation of Decay Accelerating Factor primes human germinal center B cells for phagocytosis 156 150 3

NOTCH inhibition promotes myoblast fusion by releasing HEYL repression on TMEM8C regulatory regions in foetal skeletal muscles 156 20 3

Functional Role of Second Heart Field-derived Smooth Muscle Cells in Thoracic Aortopathies in Mice 156 120 3

Platelet TSP-1 Controls Prostate Cancer-Induced Osteoclast Differentiation and Bone Marrow-Derived Cell Mobilization through TGFβ-1 14 10 3

Optogenetic control of the Bone Morphogenetic Protein signalling pathway through engineered blue light-sensitive receptors 156 20 3

The Hedgehog Co-Receptor BOC Differentially Regulates SHH Signaling During Craniofacial Development 156 20 3

Tendon and Motor Phenotypes in the Crtap-/- Mouse Model of Recessive Osteogenesis Imperfecta 156 65 10 3

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages 39 10 3

Type II collagen-positive progenitors are major stem cells to control skeleton development and vascular formation 57 20 3

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma 98 14 3

SATB homeobox 1 regulated genes in the mouse ectoplacental cone are important for placental development 156 20 3

Chikungunya Virus Infection Impairs The Function Of Osteogenic Cells 41 10 3

A Newly Identified Role for IL-22 in Bladder Immunity 174 156 27 10 3

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue 156 39 10 3

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways 156 57 20 3

Mechanosensitive activation of mTORC1 mediates ventilator induced lung injury during the acute respiratory distress syndrome 156 10 3

β-catenin Signaling Regulates Cell Fate Decisions at the Transition Zone of the Chondro-Osseous Junction During Fracture Healing 57 20 3

Cathepsin K maintains the number of lymphocytes in vivo 57 20 3

TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation. 109 39 20 3

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing 57 3

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signaling 39 3

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of CCN2. 156 15 10

AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. 72 3

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts 3

Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells through TGF-β-p38-ALDH2 pathway 108 14 10 3

The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis. 156 15 3

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 150 110 49 3

Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair 38

β-catenin-Mediated Wnt Signal Transduction Proceeds Through an Endocytosis-Independent Mechanism 20 3

TGF-β-driven downregulation the expression of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts 57 20 3

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression 110 108 14 10 3

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality 27 10 3

Plectin Ensures Intestinal Epithelial Integrity and Protects Colon Against Colitis 156 10 3

Interleukin 7 receptor (IL7R) is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells 27 10 3

Syndecan-4-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components 3

Lactate promotes cardiomyocyte dedifferentiation through metabolic reprogramming 57 3

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity 39 10 3

BAP31 regulated polarization of macrophages through C/EBP β in cutaneous wound healing 150 27 3

MSCs from syndecan-3 null mice exhibit enhanced adhesion to collagen type I, hyperactivation of the AKT pathway and increased efficacy in inflammatory arthritis 57 10 3

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation 20 3

LPS induces GFAT2 expression to promote O-GlcNAcylation and attenuate inflammation in macrophages 150 110 27 3

Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8 150 31 20 3

Mutation of the Galectin-3 Glycan Binding Domain (Lgals3-R200S) Enhances Cortical Bone Expansion in Male and Trabecular Bone Mass in Female Mice 56 3

Endogenous Galectin-3 is Required for Skeletal Muscle Repair 3

Role of syndecan-1 in the interaction between dendritic cells and T cells 27 10 3

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation 7 3

3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis 57 20 3

An Organoid for woven Bone 57 18 3

Identification, Localization and Expression of NHE Isoforms in the Alveolar Epithelial Cells 156 10 3

Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. 39 10 3

MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis 95 3

Lamin A/C functions independently from mechanical signaling during adipogenesis 57 3

Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG 186 95 3

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution 120 43 9 3

Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer 14 10 3

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammation 27 3

The long noncoding RNA Meg3 regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition 20 3

Sphingosine 1-phosphate activates the MAP3K1-JNK pathway to promote epithelial movement and morphogenesis 102 20 3

Diabetes induced decreases in PKA signaling in cardiomyocytes: the role of insulin 102 95 3

The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling 20 3

mTOR inhibition in primary neurons and the developing brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels 133 31 3

Insulin-like Growth Factor-1 Regulates the Mechanosensitivity of Chondrocytes by Modulating TRPV4 102 3

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice 110 27 10 3

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells 20 3

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine. 172 57 20 3

A Wnt-BMP4 signalling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma 20 3

IRE1? regulates macrophage polarization, PD-L1 expression and tumor survival 150 27 14 10 3

Identification of a new regulation pathway of EGFR and E-cadherin dynamics 102 34 3

Deletion and overexpression of the scaffolding protein IQGAP1 promotes HCC 108 14 3

Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells 98 14 10 3