Topic 152

tumor cancer tumors patient derived subtypes heterogeneity adenocarcinoma pdac pancreatic pdx xenograft patients metastatic aggressive ductal biology therapeutic subtype treatment transcriptomic cell metastases clinical therapy samples organoids relapse rna profiling sequencing cells chemotherapy lines stratification phenotype single subpopulations signatures disease phenotypes targets matched identify targeted refractory vivo metastasis models neuroendocrine preclinical like differential resistance breast inhibition stromal therapies distinct plasticity heterogeneous microenvironment drug analysis bulk malignant mutations needle relevant prostate tissue basal signaling advanced glioblastoma orthotopic molecular epithelial classical tumoral clinically stem precision treatments classification xenografts organoid progression analyses phenotypic origin potential gbm outcome growth subpopulation malignancy caf biopsy define

54 items. Top items listed below.

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy 152 14 9 3

Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer 152 14 9 3

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures 152 14 9 3

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies 152 148 14 9 4

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics 152 14 9

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway 152 14 9 3

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer 152 14 9 3

Single cell analysis of colorectal cancer identifies mitogen-activated protein kinase as a key driver of tumor cell plasticity 152 148 142 14 9 3

Multiplex-inhibitor bead mass spectrometry reveals differential kinome signatures in newly diagnosed and recurrent glioblastoma 152 14 9 3

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer 152 142 14 9 3

Plasticity as an Underlying Mechanism of Tumor Heterogeneity in Breast Cancer 152 14 9

Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumors 152 126 14 10 3

Basal-like and Classical cells coexistence in pancreatic cancer revealed by single cell analysis 152 14 9

Single-cell RNA-sequencing of peripheral neuroblastic tumors reveals an aggressive transitional cell state at the junction of an adrenergic-mesenchymal transdifferentiation trajectory 152 14 9 3

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment 152 148 14 9

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells 152 14 10 3

Inducible transgene expression in PDX models in vivo identifies KLF4 as therapeutic target for B-ALL 152 126 14 10 3

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity 152 14 3

A 'one-two punch' therapy strategy to target chemoresistance in estrogen receptor positive breast cancer 152 126 14 10 3

Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts 126 14 10 9

A small molecule screen identified N-Acetyl-L-cysteine for promoting ex vivo growth of single circulating tumor cells 152 14 10 3

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer 152 14 9 3

An Integrative Genetic, Epigenetic and Proteomic Characterization of Pancreatic Neuroendocrine Neoplasms (PanNENs) defines Distinct Molecular Features of α- and β-cell like Subgroups 173 152 14 9

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases 152 14 10 9

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells 152 126 14 10 3

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment 152 14 9 3

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer 152 142 14 9 3

Global computational alignment of tumor and cell line transcriptional profiles 43 14 9 4

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes 152 14 9 3

RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon 152 142 14 9 3

Pharmacological inhibition of the ALK axis elicits therapeutic potential in Consensus Molecular Subtype 1 colon cancer patients 152 14 10 3

ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancer 108 14 3

Distinct Roles of Tumor-Associated Mutations in Collective Cell Migration 152 14 10

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS 152 14 10

Cancer-associated fibroblast compositions change with breast cancer progression linking S100A4 and PDPN ratios with clinical outcome 152 14 9 3

Fishing for contact: Modeling perivascular glioma invasion in the zebrafish brain. 152 126 14 10

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance 152 126 14 10 3

Patient-derived xenografts and organoids model therapy response in prostate cancer 152 126 14 10 9

Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering 152 14 4

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer 14 9 3

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis 152 14 10 3

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments 152 14 10

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma 152 14 3

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets 152 14 10 3

Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy 14 10 9

A Molecular Taxonomy of Tumors Independent of Tissue-of-Origin 152 142 14 9

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies 152 126 14 10 9 3

Drug-tolerant idling melanoma cells exhibit theory-predicted metabolic low-low phenotype 152 14 3

Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication 152 57 9

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer 152 14 10

Characterizing the tumor microenvironment of metastatic ovarian cancer by single cell transcriptomics 148 14 9 3

Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum 98 14 9 4

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers 126 14 10 3

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation 152 14 10 3

Establishment of a simplified preparation method for single-nucleus RNA-sequencing and its application to long-term frozen tumor tissues 175 43 4

Convergent network effects along the axis of gene expression during prostate cancer progression 14 9

A multi-layered systems approach for renal cell carcinoma 14 9

HDAC and MAPK/ERK inhibitors cooperate to reduce viability and stemness phenotype in medulloblastoma 186 108 14 10 3

Oncogenic memory underlying minimal residual disease in breast cancer 152 14 10 3

Quantitative in vivo analyses reveal a complex pharmacogenomic landscape in lung adenocarcinoma 14 9

Human pluripotent stem cell modeling of tuberous sclerosis complex reveals lineage-specific therapeutic vulnerabilities 152 57 14 3

RRBP1 rewires cisplatin resistance in Oral Squamous Cell Carcinoma by regulating YAP-1 14 10 3

LSD1 promotes secretory cell specification to drive BRAF mutant colorectal cancer 142 14 3

Intracellular Optical Doppler Phenotypes of Chemosensitivity in Human Epithelial Ovarian Cancer 189 152 14 10

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer 126 14 10 3

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells 152 14 9 4

Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma 14 9 4

Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer 152 14 10 3

A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 186 14 9 3

Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model 126 14 10 9 3

Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell Transcriptomics 189 148 14 9 3

Integration of Biodynamic Imaging and RNA-seq predicts chemotherapy response in canine diffuse large B-cell lymphoma 112 14 9 4

Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach 126 14 10 3

Divergent resistance mechanisms to immunotherapy explains response in different skin cancers. 173 14 10 3

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression 148 14 9 3

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells 7

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq 14 9

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity 108 14 10 3

Respiratory complex and tissue lineage drive mutational patterns in the tumor mitochondrial genome 142 14 9 3

Hormonal regulation of Semaphorin 7a in ER+ breast cancer drives therapeutic resistance 126 14 10 3

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker 14 10 9

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer 148 14 9 3

Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient specific signaling networks 186 14 9 3

Longitudinal cancer evolution from single cells 43 4

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4 128 14 3

High-resolution positron emission microscopy of patient-derived tumor organoids 14 10

Analysis of single-cell RNA-seq data from ovarian cancer samples before and after chemotherapy links stress-related transcriptional profile withchemotherapy resistance 14 9

Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma 98 14 10 3

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies 126 14 10 3

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells 173 88 14 9 3

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model 186 14 10 3

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to PARP inhibition in lung cancer 142 14 9 3

Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis 108 14 10 3

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance. 126 14 10 3

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma 14 9 3

Taxane induces attenuation of the CXCR2/BCL-2 axis and sensitize prostate cancer to platinum-based treatments 126 14 10 3

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma 14 10

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population During Temozolomide Therapy in Glioblastoma 186 126 14 10 3

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts 126 14 10

Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships 148 43 14 9